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Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma.IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.Nitrogen dioxide (NO2) is an environmental toxin that correlates with asthma severity, exacerbation, and risk o

A total of 25 specimens of Cavia porcellus (guinea pig), 5 Dasyprocta agouti (agouti), and 22 Calomys callosus (vesper mice) were inoculated with infective eggs of Lagochilascaris minor.The inoculum was prepared with aptamil allerpro embryonated eggs and orally administered to each individual animal through an esophagus probe.In parallel, 100 speci

Histone lysine specific demethylase 1 (LSD1) has been recognized as an important modulator in post-translational process in epigenetics.Dysregulation of LSD1 has been implicated in the development of various cancers.Herein, we report the discovery 100w products of the hit compound 8a (IC50 = 3.93??mol/L) and further medicinal chemistry efforts, lea